SML0029

Glycopyrrolate

≥98% (HPLC)

• Sinónimos: α-cyclopentylmandelic acid ester with 3-hydroxy-1,1-dimethylpyrrolidinium bromide, 1-methyl-3-pyrrolidyl α-cyclopentylmandelate methobromide, 1-methyl-3-pyrrolidyl α-phenyl-α-cyclopentylglycolate methobromide, 3-(2-phenyl-2-cyclopentylglycoloyloxy)-1,1-dimethylpyrrolidinium bromide, 3-hydroxy-1,1-dimethylpyrrolidinium bromide α-cyclopentylmandelate, AHR-504, Copyrrolate, Gastrodyn, NSC 250836, NSC 251251, NSC 251252, NVA-237, glycopyrronium bromide
• Fórmula empírica (notación de Hill): C₁₉H₂₈NO₃ · Br
• Número CAS: 596-51-0
• Peso molecular: 398.33
• NACRES: NA.77
• PubChem Substance ID: 329825100
• UNSPSC Code: 12352200
• EC Number: 209-887-0
• MDL number: MFCD00072137
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥24 mg/mL
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: [Br-].C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)c3ccccc3
• InChI: 1S/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1
• InChI key: VPNYRYCIDCJBOM-UHFFFAOYSA-M
• Gene Information: human ... CHRM1(1128), CHRM3(1131)

Descripción

General description

Glycopyrrolate is a quaternary ammonium compound and it shows structural similarity with atropine.

Biochem/physiol Actions

Glycopyrrolate is long-acting muscarinic antagonist (LAMA). It is kinetically selective muscarinic M3 receptor antagonist.

Long-acting muscarinic antagonist (LAMA); anticholinergic; antispasmodic; preanesthetic medicant

Glycopyrrolate is an anti-cholinergic drug. It is a potent controller of drooling, observed in children affected with cerebral palsy. Compared to other muscarinic antagonists, glycopyrrolate has lower CNS (central nervous system) penetration.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302,H319
• Indicaciones de precaución: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Clase de almacenamiento: 11 - Combustible Solids
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2