SMB00577

Diallyl trisulfide

≥97% (HPLC)

• Sinónimos: Allyl trisulfide, Di-2-propenyl trisulfide
• Fórmula empírica (notación de Hill): C₆H₁₀S₃
• Número CAS: 2050-87-5
• Peso molecular: 178.34
• NACRES: NA.25
• PubChem Substance ID: 329825066
• UNSPSC Code: 12352200
• EC Number: 218-107-8
• MDL number: MFCD00040025

Propiedades

• biological source: Allium sativum L.
• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: liquid
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: C=CCSSSCC=C
• InChI: 1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
• InChI key: UBAXRAHSPKWNCX-UHFFFAOYSA-N

Descripción

General description

Diallyl trisulfide (DATS) is one of the stable naturally occurring bioactive polysulfide compounds found in Allium vegetables, especially in garlic.

Application

Diallyl trisulfide (DATS) has been used as an exogenous hydrogen sulfide (H₂S)donor to study the effects on proliferation, apoptosis, and autophagy of human urothelial carcinoma (UC) cells in vitro.

Biochem/physiol Actions

Diallyl trisulfide elicits cardioprotective and anti-metabolic syndrome (MetS) effects against ex vivo induced myocardial ischemia/reperfusion (I/R) injury in MetS rats (male Wistar albino). It is a potent anti-cancer agent and acts by modulating different cancer-related pathways, inducing cell cycle arrest, apoptosis, metastasis, and angiogenesis in in vitro studies. DATS is also an effective therapeutic agent against multidrug resistance in triple-negative breast cancer (TNBC). DATS and its nanoemulsions display high antifungal activity against wood-rotting fungi such as T. hirsuta and L. sulphureus. It also provides protection against brain damage induced by ischemia/reperfusion (I/R) by activating nuclear factor erythroid 2-related factor 2 (Nrf2) in rat brains.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H301
• Hazard Classifications: Acute Tox. 3 Oral
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• Indicaciones de precaución: P264 - P270 - P301 + P310 + P330 - P405 - P501