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SCP0169

Sigma-Aldrich

HIV-1 Tat Peptide

HIV-TAT (48-57)
1 de 1 reseñadores recibieron un producto de muestra o participaron en una promoción

≥95% (HPLC), lyophilized powder

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1 MG
188,00 €

188,00 €


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1 MG
188,00 €

About This Item

Fórmula empírica (notación de Hill):
C65H124N34O13
Peso molecular:
1589.90
Código UNSPSC:
12352202
NACRES:
NA.32

188,00 €


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Nombre del producto

HIV-TAT (48-57),

Ensayo

≥95% (HPLC)

Formulario

lyophilized

composición

Peptide Content, ≥55%

condiciones de almacenamiento

protect from light

temp. de almacenamiento

−20°C

Amino Acid Sequence

Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-NH2

Descripción general

Human immunodeficiency virus (HIV)-transactivator of transcription (Tat), a regulatory protein is coded by the Tat gene of HIV-1. Tat is made up of two exons, highly conserved regions, and subtype-specific regions.[1]

Acciones bioquímicas o fisiológicas

Human immunodeficiency virus (HIV)-transactivator of transcription (Tat) participates in the pathogenesis of HIV-related complications. Tat protein is also involved in HIV-related cardiac dysfunction.[1] HIV-TAT (48-57) is used to facilitate the internalization of synthetic peptides.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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S-M Lee et al.
Clinical and experimental immunology, 161(3), 504-511 (2010-07-22)
The immune receptor expressed on myeloid cells 1 (IREM-1) has been known to regulate the activities of myeloid cells through its immunoreceptor tyrosine-based inhibition motifs (ITIMs) in its intracellular region. In order to investigate its effect on macrophage activation, a
Yanan Jiang et al.
Journal of translational medicine, 16(1), 121-121 (2018-05-10)
The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which
S-M Lee et al.
Clinical and experimental immunology, 167(3), 438-446 (2012-02-01)
The immune receptor expressed on myeloid cells 1 (IREM-1/CD300F) has been shown to inhibit various inflammatory processes in myeloid cells, such as macrophages and mast cells. IREM-1 exerts its inhibitory effect through its intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). In

Preguntas

Revisiones

1 de 1 reseñadores recibieron un producto de muestra o participaron en una promoción

Filtros activos

    • Reseña 1
    • Votos 3
    1 de 5 estrellas.

    Purchase a different product

    Quite disappointed in this product. For one, they do not provide any information on reconstitution of this lyophilized powder, not even whether to use dH20 or not. Additionally, please look closely at the 3 cited papers that allegedly used this product. One is a review that didn't actually use the product, and the other two are from the same lab that published what looks to be the same experiment twice, but without sufficient methodology. They list that, "Fusion proteins containing ITIMs and HIV-TAT48–57 and its negative control containing only HIV-TAT48–57 were custom-designed and synthesized by Peptron Inc. (Daejeon, Korea)" which is not this product? Additionally, their only methodology in terms of use does not include reconstitution, merely this sentence hidden below a figure, "Cells were pre-treated with 5 µM of TAT, TAT–YADL, TAT–YVTM, TAT–YASL, TAT–YCNM or TAT–YSTI for 30 min before stimulation with 1 µg/ml of lipopolysaccharide (LPS) for 24 h."

    When I contacted a rep about my concerns they said they couldn't help with reconstitution instructions and I should have checked to see if they had instructions before purchasing.... a less than stellar response. Save yourself the time, money, and hassle and find a different product.

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    ¿Le ha resultado útil?

    1. Respuesta de Sigma-Aldrich Corporation:

      Thank you for taking the time to leave a review. We are sorry to hear that your experience did not meet expectations. Our Technical Service team has reached out to you with additional resources in effort to resolve this issue. We apologize for any inconvenience this may have caused.

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