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SCP0004

γ Secretase Inhibitor

≥95% (HPLC)

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Talla/SKUDisponibilidadPrecio
5 mg
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276,00 €

Acerca de este artículo

Fórmula empírica (notación de Hill):
C26H41N3O5
Peso molecular:
475.62
NACRES:
NA.32
UNSPSC Code:
12352200

276,00 €

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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

General description

Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors.

Application

γ Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells.

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Este artículo
SCP0025565773565763
γ Secretase Inhibitor ≥95% (HPLC)

Sigma-Aldrich

SCP0004

γ Secretase Inhibitor

APP γ Secretase Inhibitor

Sigma-Aldrich

SCP0025

APP γ Secretase Inhibitor

γ-Secretase Inhibitor XII The γ-Secretase Inhibitor XII controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Sigma-Aldrich

565773

γ-Secretase Inhibitor XII

γ-Secretase Inhibitor VI The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Sigma-Aldrich

565763

γ-Secretase Inhibitor VI

description

≥95% (HPLC)

description

-

description

The γ-Secretase Inhibitor XII controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

description

The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

lyophilized

form

lyophilized

form

solid

form

solid

storage condition

protect from light

storage condition

protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

composition

Peptide Content, ≥85%

composition

Peptide Content, ≥75%

composition

-

composition

-

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Preguntas

  1. What are the reconstitution instructions for this compound? I checked the SDS, COA, and spec sheet. Also what is the CAS#?

    1 respuesta

    1. The solubility of this product is in DMSO at 1 mg/ml or higher.

      In biological experiments, water is the most preferred solvent. However, several organic compounds are either not soluble in water or degrade rapidly in the presence of moisture. If DMSO is a recommended solvent, it is best to use a fresh stock bottle that is deemed free of any moisture. Any contaminating moisture may accelerate the degradation of the compound in question or may render it insoluble. It is best to make the initial serial dilutions only in DMSO and then add the final diluted sample to your buffer or the incubation medium. The final concentration of DMSO in vivo should not exceed more than 0.1 %.

      Please see the general information about the use of inhibitors in animals and these data sheets from other γ-Secretase Inhibitors from Calbiochem, which may be useful:
      http://www.emdmillipore.com/product/-Secretase-Inhibitor-I-Calbiochem,EMD_BIO-565750#anchor_PDS
      http://www.emdmillipore.com/product/-Secretase-Inhibitor-XX-CAS-209984-56-5-Calbiochem,EMD_BIO-565789#anchor_PDS

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