SAB5701928

Anti-Phospho-MLKL-S454 antibody produced in rabbit

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: liquid
• reactividad de especies: human, mouse
• concentración: 0.464 mg/mL
• técnicas: western blot: 1:500-1:2000
• Nº de acceso UniProt: Q8NB16
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pSer454)
• Información sobre el gen: human ... Phospho-MLKL-S454(197259)

Descripción

Descripción general

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Inmunógeno

A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL.

Forma física

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable