IgG2c codes for Igh-1b. In mice, IgG2a and IgG2c are arranged in tandem on identical chromosome as two visible loci.
Especificidad
This antibody reacts to the Fc region of mouse IgG2c. No cross reactivity with mouse IgG1, IgG2a, IgG2b, IgG3, IgM, IgA, IgE, human IgG, or rat IgG.
Inmunógeno
Purified mouse IgG2c whole molecule
Acciones bioquímicas o fisiológicas
Mouse IgG2c generate several unique non-bonded interactions between the BC, DE and FG loops than mIgG2b. It connects to FcγRIV (Fc γ receptor IV) with a high affinity in the complex-type glycoform. In mice, IgG2c has unique immune profiles like, response, immune-decoration, because of their difference in protein sequence.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
¿No encuentra el producto adecuado?
Pruebe nuestro Herramienta de selección de productos.
Mouse IgG2c Fc loop residues promote greater receptor-binding affinity than mouse IgG2b or human IgG1.
Daniel JF, et al.
PLoS ONE, 13(2), e0192123-e0192123 (2018)
Possible allelic structure of IgG2a and IgG2c in mice.
Zhang Z, et al.
Molecular Immunology, 50(3), 169-171 (2012)
Preguntas
Revisiones
★★★★★ Sin puntuación
Filtros activos
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
