Solute carrier family 12 member 1 (SLC12A1) is a Na+-K+-Cl- transporter and it is expressed in the thick ascending loop of kidneys in rats. The gene ID of the protein is 25065.
Especificidad
Detects ~160 kDa.
Inmunógeno
AA109 to 129 of the rat sequence
Acciones bioquímicas o fisiológicas
Solute carrier family 12 member 1 (SLC12A1) functions in water reabsorption in the kidneys.
Características y beneficios
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Forma física
PBS, 50% glycerol, and 0.09% sodium azide
Cláusula de descargo de responsabilidad
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Biochemical and biophysical research communications, 453(3), 356-361 (2014-09-30)
Sodium reabsorption via Na-K-2Cl cotransporter 2 (NKCC2) in the thick ascending limbs has a major role for medullary osmotic gradient and subsequent water reabsorption in the collecting ducts. We investigated intrarenal localization of three isoforms of NKCC2 mRNA expressions and
Frontiers in physiology, 12, 642274-642274 (2021-04-20)
Emerging evidence is showing that apelin plays an important role in regulating salt and water balance by counteracting the antidiuretic action of vasopressin (AVP). However, the underlying mechanism remains unknown. Here, we hypothesized that (pro) renin receptor (PRR)/soluble prorenin receptor
Salt-sensitive hypertension involves a renal defect preventing the kidney from eliminating excess NaCl. The thick ascending limb of Henle loop reabsorbs ≈ 30% of filtered NaCl via the apical Na-K-2Cl cotransporter (NKCC2). Higher NKCC2 activity and Cl reabsorption have been
American journal of physiology. Renal physiology, 307(2), F137-F146 (2014-05-23)
This study aims to understand the extent to which modulation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 differential splicing affects NaCl delivery to the macula densa. NaCl absorption by the thick ascending limb and macula densa cells is mediated by apical NKCC2.
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