SAB4504721
Anti-phospho-p47 phox (pSer345) antibody produced in rabbit
affinity isolated antibody
Sinónimos:
Anti-CGD1, Anti-NCF1A, Anti-NOXO2, Anti-SH3PXD1A, Anti-p47phox
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
antigen 44 kDa
reactividad de especies
rat, human, mouse
concentración
~1 mg/mL
técnicas
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pSer345)
Información sobre el gen
human ... NCF1(653361)
Categorías relacionadas
Descripción general
The neutrophil cytosolic factor 1 (NCF1), also known as p47phox gene, spanning 15kb with 11 exons, is mapped to human chromosome 7q11.23. The gene codes for a 390 amino acid protein, which is a novel component of the NADPH oxidase complex.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser345.
Immunogen Range: 311-360
Immunogen Range: 311-360
Acciones bioquímicas o fisiológicas
Neutrophil cytosolic factor 1 (NCF1) stimulates the production of reactive oxygen species (ROS) under hyperoxic condition. The above process can be inhibited by the NCF1 inhibitor diphenylene iodonium (DPI) and apocynin. Mutation in the gene leads to a rare congenital immune deficiency called, chronic granulomatous disease (CGD). Deletion of NCF1 gene, which is a vital component of NADPH oxidase complex implicated in generation of oxidative stress, leads to Williams syndrome. It also act as a modifier of vascular stiffness.
Características y beneficios
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Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
U Francke et al.
American journal of human genetics, 47(3), 483-492 (1990-09-01)
Chronic granulomatous disease (CGD) is a heterogeneous group of inherited disorders of impaired superoxide production in phagocytes. The most common X-linked recessive form involves the CYBB locus in band Xp21.1 that encodes the membrane-bound beta subunit of the cytochrome b558
Beth A Kozel et al.
Hypertension (Dallas, Tex. : 1979), 63(1), 74-79 (2013-10-16)
Williams syndrome is caused by the deletion of 26 to 28 genes, including elastin, on human chromosome 7. Elastin insufficiency leads to the cardiovascular hallmarks of this condition, namely focal stenosis and hypertension. Extrapolation from the Eln(+/-) mouse suggests that
Astghik Hayrapetyan et al.
Biochimica et biophysica acta, 1832(10), 1662-1672 (2013-05-22)
Chronic granulomatous disease (CGD) is a rare congenital disorder in which phagocytes cannot generate superoxide (O2(-)) and other microbicidal oxidants due to mutations in one of the five components of the O2(-)-generating NADPH oxidase complex. The most common autosomal subtype
Lingping Zhang et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32(1), 59-62 (2016-01-06)
To observe the effects of NADPH oxidase inhibitor diphenylene iodonium (DPI) and apocynin on the generation of reactive oxygen species (ROS) induced by p47phox and the mechanism of p47phox-induced ROS production under hyperoxic conditions. Peripheral blood mononuclear cells (PBMCs) were
Trishan Vaikunthanathan et al.
EBioMedicine, 95, 104778-104778 (2023-09-02)
Dysregulated inflammatory responses and oxidative stress are key pathogenic drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells (Tregs) are essential to prevent excessive immune activation and maintain tissue homeostasis. While inflammatory cues are well known
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