AXL (receptor tyrosine kinase) is also termed as Ark, UFO or Tyro7. This gene is overexpressed in pancreatic cancer tissues. AXL belongs to the receptor tyrosine kinase family. It is obtained as a transforming gene from human leukemia cells. AXL is mapped to human chromosome 19q13.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human AXL around the phosphorylation site of Tyr691.
Immunogen Range: 657-706
Acciones bioquímicas o fisiológicas
AXL (receptor tyrosine kinase) controls innate immune responses. It participates in cellular transformation and tumor progression. Overexpression of AXL is characterized with higher liability for lymphatic metastases.
Características y beneficios
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Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
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AXL receptor tyrosine kinase ligand (AXL), a tyrosine kinase receptor that is commonly overexpressed in numerous types of cancer, significantly promotes drug resistance and metastasis in tumor cells. Inhibition of the AXL/growth arrest-specific 6 (Gas6) signaling pathway is emerging as
Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses.
Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS. Direct inhibition of KRAS through pharmacological means remains a challenge; however, targeting key KRAS effectors has therapeutic potential. We investigated the contribution of TANK-binding kinase 1 (TBK1), a
AXL signaling in primary sensory neurons contributes to chronic compression of dorsal root ganglion-induced neuropathic pain in rats.
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