SAB4501174
Anti-Connexin 43 Antibody
rabbit polyclonal
Sinónimos:
CX43, CXA1, CXN-43, Connexin 43, Gap junction 43 kDa heart protein
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100 μG
390,00 €
390,00 €
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100 μG
390,00 €
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
390,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
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Nombre del producto
Anti-Connexin 43 antibody produced in rabbit, affinity isolated antibody
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen 43 kDa
reactividad de especies
mouse, human, rat
concentración
~1 mg/mL
técnicas
ELISA: 1:20000
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... GJA1(2697)
Descripción general
Connexin 43 belongs to the connexin protein family that forms gap junction. This protein is highly expressed in neurons and radial glia during development and in astrocytes in adult brains.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human Connexin 43.
Immunogen Range: 332-381
Immunogen Range: 332-381
Aplicación
Anti-Connexin 43, C-Terminal antibody produced in rabbit has been used in flow cytometry.[1]
Acciones bioquímicas o fisiológicas
In rodents, connexin-43 (Cx-43) shows specific temporal patterns of expression during brain development. Experimental studies reveal that, connexin-43 expression increases in the brain during sheep ontogenesis.This protein might play a crucial role in neuronal migration as it resides in radial glial fibers which are closely associated with migrating neurons. It is also involved in transmembrane NAD+ transport. connexin-43, which is an element of gap junction, helps in cell–cell communication. Cx-43 is known to induce [Ca2+] i burst phenomenon in uterine artery endothelial cells (UAECs).
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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S Bruzzone et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(1), 10-12 (2000-12-02)
A previously unrecognized passive transport for pyridine dinucleotides has been described recently in the plasmamembrane of several mammalian cells. Despite elucidation of some functional and kinetic properties of this transport system, it is still undefined at the molecular level. Therefore
Grazyna B Sadowska et al.
Brain research, 1255, 51-56 (2008-12-23)
Gap junctions are specialized membrane structures that mediate intercellular communication and facilitate passage of ions and small molecules between adjacent cells. Connexins comprise a multigene family of transmembrane proteins that form gap junctions. Connexin-32 and connexin-43 are among the most
B Nadarajah et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(9), 3096-3111 (1997-05-01)
Gap junctions are membrane channels that mediate the direct passage of ions and molecules between adjacent cells. Recent tracer coupling and optical recording studies have revealed the presence of gap junction-mediated communication between neurons during neocortical development. We have visualized
Fu-Xian Yi et al.
Biology of reproduction, 82(1), 66-75 (2009-09-11)
Endothelium-mediated vasodilation is specifically enhanced in uterine circulation during pregnancy, and production of nitric oxide (NO) is increased in response to a wide array of agonists. Uterine artery endothelial cells from nonpregnant (NP-UAECs) or pregnant (P-UAECs) ewes maintained in culture
Rosario Gajardo-Gómez et al.
International journal of molecular sciences, 21(7) (2020-04-09)
At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively known as HIV-associated neurocognitive disorders (HAND). The molecular mechanisms that amplify damage within the brain of HIV-infected individuals are
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