SAB4200652
Monoclonal Anti-TOM1L1 antibody produced in mouse
clone 3F12, purified from hybridoma cell culture
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About This Item
Código UNSPSC:
12352203
origen biológico
mouse
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
3F12, monoclonal
Formulario
buffered aqueous solution
mol peso
antigen ~53 kDa
reactividad de especies
human, bovine, monkey
concentración
~1 mg/mL
técnicas
immunoblotting: 0.5-1 μg/mL using using whole extracts of HeLa cells.
immunofluorescence: 5-10 μg/mL using using HeLa cells.
isotipo
IgG1
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... TOM1L1(10040)
Descripción general
The gene TOM1L1 (target of myb1 like 1 membrane trafficking) is mapped to human chromosome 17q23. The protein has a VHS (Vps27p/Hrs/Stam) domain at the N-terminal, a GAT (GGA (Golgi-localizing, γ-adaptin ear domain homology, ADP-ribosylation factor (Arf)-binding protein and Tom) domain at the center and interaction motifs at the C-terminal.
Inmunógeno
immunized with a TOM1L1 fusion protein.
Acciones bioquímicas o fisiológicas
TOM1L1 (target of myb1 like 1 membrane trafficking) is an adaptor protein, which is involved in vesicular trafficking as well as intracellular signaling. It negatively controls the mitogenic and transforming functions in fibroblasts by working as a substrate for SRC (tyrosine protein kinase). It is involved in EGF (epidermal growth factor)-mediated internalization of EGF receptor. TOM1L1 is downregulated in cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Béatrice Orsetti et al.
Cancer research, 64(18), 6453-6460 (2004-09-18)
Chromosome 17 is severely rearranged in breast cancer. Whereas the short arm undergoes frequent losses, the long arm harbors complex combinations of gains and losses. In this work we present a comprehensive study of quantitative anomalies at chromosome 17 by
Yu Qi et al.
Anticancer research, 30(9), 3535-3539 (2010-10-15)
Src-family tyrosine kinases (SFKs) play critical roles in regulating cellular differentiation and proliferation. Src-activating and signaling molecule (Srcasm) is a novel molecule that down-regulates SFK activity and promotes cell differentiation. The aim of this study was to determine whether Srcasm
Ahmed Elmarghani et al.
Mediators of inflammation, 2009, 416298-416298 (2010-02-26)
TOM1L (target of Myb-1 Like) was identified as a binding partner for the full length and catalytically-active Lck in a yeast 2-hybrid screening assay. Here we show that in Jurkat T cells stimulated by CD3/CD28 coligation where the expression of
Ning Sheng Liu et al.
The EMBO journal, 28(22), 3485-3499 (2009-10-03)
Although many proteins have been shown to participate in ligand-stimulated endocytosis of EGF receptor (EGFR), the adaptor protein responsible for interaction of activated EGFR with endocytic machinery remains elusive. We show here that EGF stimulates transient tyrosine phosphorylation of Tom1L1
Audrey Sirvent et al.
Molecular & cellular proteomics : MCP, 11(12), 1937-1950 (2012-10-02)
The non-receptor tyrosine kinase SRC is frequently deregulated in human colorectal cancer (CRC), and SRC increased activity has been associated with poor clinical outcomes. In nude mice engrafted with human CRC cells, SRC over-expression favors tumor growth and is accompanied
Filtros activos
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