Histones are considered as the important constituents of chromatin. They are classified into core histones and linker histones. Histone H3 gene codes for a H3 protein sequence. This H3 gene is located on human chromosome 1 (1q42).
Inmunógeno
synthetic peptide containing acetylated Lys56 of human histone H3, conjugated to KLH. The corresponding sequence is identical in many species including rat and mouse histone H3.
Aplicación
Anti-acetyl-Histone H3 [Ac-Lys56] has been used in western blot analysis.[1]
Acciones bioquímicas o fisiológicas
Core histones and linker histones are known possesses inter and intra-specific amino acid sequence variability. Histone modifications are thought to play an important role in cancer and disease. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. In human embryonic stem cells, histone H3 Lys56 acetylation is associated to the core transcriptional network.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Environmental science and pollution research international, 31(20), 30149-30162 (2024-04-11)
Nanoparticles, particularly magnesium oxide nanoparticles (MgO-NPs), are increasingly utilized in various fields, yet their potential impact on cellular systems remains a topic of concern. This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae
Histone Variants: Signaling or Structural Modules
Handbook of Cell Signaling, 2409-2425 (2010)
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
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