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Merck

SAB4200283

Sigma-Aldrich

Anti-Tensin 1 antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

Sinónimos:

Anti-TNS1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 225 kDa (rat)
antigen ~150 kDa (human)

reactividad de especies

rat, human, chicken

validación mejorada

recombinant expression
Learn more about Antibody Enhanced Validation

concentración

~1.0 mg/mL

técnicas

immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded rat heart.
indirect immunofluorescence: 3-6 μg/mL using chicken embryo fibroblast cells.
western blot: 1-2 μg/mL using lysates of HEK-293T cells overexpressing human tensin 1

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... TNS1(7145)
mouse ... Tns1(21961)
rat ... Tns1(301509)

Descripción general

Tensin 1 (TNS1) is encoded by the gene mapped to human chromosome 2q35. The encoded protein is localized to focal adhesions and is mainly expressed in renal tubular epithelial cells (TECs).

Inmunógeno

synthetic peptide corresponding to a sequence located in the internal region of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.

Aplicación

Anti-Tensin 1 antibody may be used in immunofluorescence and immunohistochemistry.
Anti-Tensin 1 antibody produced in rabbit has been used in immunostaining and immunoblotting.

Acciones bioquímicas o fisiológicas

Tensin 1 (TNS1) contributes to transforming growth factor (TGF)-β-induced myofibroblast differentiation and extracellular fibronectin and collagen matrix formation. Disruption in the gene and associated signaling might hinder tissue fibrosis. The encoded protein anchors to stress fibers by interacting with cytoplasmic tails of integrins and increases metastatic abilities of cancer cells. Tensin plays a vital role in activation of the c-Jun N-terminal kinases (JNK) and p38 pathways.
Tensin 1 associates with actin, integrin, FAK, p130Cas, DLC-1 and protein phosphatase PP1 which affects cell polarization, migration and invasion. Tensin 1 undergoes extensive Ser/Thr and Tyr phosphorylation induced by extracellular matrix (ECM), various growth factors and oncogenes. In addition, tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Tensin is potentially involved in extracellular matrix production in mesangial cells.
Yamashita M
Histochemistry and Cell Biology, 121, 245-254 (2004)
Genetic association analyses highlight biological pathways underlying mitral valve prolapse
Dina C
Nature Genetics, 47, 1206?1211-1206?1211 (2015)
Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation.
Bernau K
American Journal of Respiratory Cell and Molecular Biology, 56, 465-476 (2017)
Tensin can induce JNK and p38 activation.
Katz BZ
Biochemical and Biophysical Research Communications, 272, 717-720 (2000)
Tensin
Lo S H
The International Journal of Biochemistry & Cell Biology, 36(1), 31-34 (2004)

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