Cluster of differentiation (CD4) encodes a T-cell surface glycoprotein CD4. In human chromosome, the gene CD4 is localized on 12p13.31.
Inmunógeno
raised against a 193 amino acid recombinant protein from near the amino terminus of human CD4.
Acciones bioquímicas o fisiológicas
Cluster of differentiation (CD4) mutation in single nucleotide causes OKT4 (Leu-3 T4) epitope deficiency. CD4 plays a major role in collateral artery formation by recruiting macrophages at the active site and through triggering the synthesis of arteriogenic cytokines.
Características y beneficios
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Descripción de destino
CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.
Forma física
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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Gene-expression profiling of titanium-cell interaction
Kim CS, et al.
The Journal of Korean Academy of Prosthodontics, 43(3), 393-408 (2005)
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