Intraflagellar transport 88 (IFT88) is a liver tumor suppressor gene. It consists of 824 amino acids and possesses tetratricopeptide repeats.
Inmunógeno
Peptide with sequence C-KKRIDEDDFADEE from the C Terminus of the protein sequence according to NP_783195.2; NP_006522.2.
Acciones bioquímicas o fisiológicas
Intraflagellar transport 88 (IFT88) is involved in cilia formation. It is linked to polycystic kidney disease. In mitosis, the protein has a crucial role in spindle orientation. IFT88 is downregulated in hepatocellular carcinoma.
Características y beneficios
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Forma física
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Polaris, a Protein Involved in Left-Right Axis Patterning, Localizes to Basal Bodies and Cilia
Patrick D
Molecular Biology of the Cell (2001)
The cilia protein IFT88 is required for spindle orientation in mitosis.
Delaval B
Nature Cell Biology (2011)
Tg737 signaling is required for hypoxia-enhanced invasion and migration of hepatoma cells.
You N
Journal of Experimental & Clinical Cancer Research (2012)
The molecular biology of polycystic kidney disease
Noel S
Pediatric Nephrology (Berlin) (1998)
Preguntas
Revisiones
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Filtros activos
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