SAB2500409

Anti-FOXA2/HNF3B antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-Forkhead box A2, Anti-HNF3B, Anti-Hepatic nuclear factor-3-β, Anti-MGC19807, Anti-TCF3B
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: goat
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human, mouse, rat
• técnicas: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Nº de acceso UniProt: Q9Y261
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... FOXA2(3170)

Descripción

Descripción general

Forkhead box A2 (FOXA2), also known as hepatocyte nuclear factor 3-β (HNF3-β), is encoded by the gene mapped to human chromosome 20p11.21. It is expressed in the liver, pancreas, intestine, and lungs. FOXA2 is a member of forkhead box (FOX) gene family and is characterized by a DNA binding “winged helix domain”.[1]

Inmunógeno

Peptide with sequence C-GVYSRPIMNSS from the C Terminus of the protein sequence according to NP_068556.1; NP_710141.1.

Acciones bioquímicas o fisiológicas

Forkhead box A2 (FOXA2) or HNF3β is associated with embryonic formation of the primitive streak and endoderm. It also plays an important role in airway epithelial differentiation and is extensively expressed in type II pneumocytes. Decreased expression of FOXA2 is observed in lung cancer and non-small-cell lung cancer (NSCLC). FOXA2 plays a vital role in normal pancreatic β-cell function and aberration in the expression of the gene leads to hyperinsulinemic hypoglycemia. It also has an essential role in pancreatic α-cell differentiation. FOXA2 acts a regulator of the network of genes associated with intestinal epithelial cell function. Increased expression of FOXA2 in MKN-45 cells (human gastric cancer cell line) elevates E-cadherin expression and inhibits gastric cancer cell migration and invasion and therefore, FOXA2 is expressed at low levels in gastric adenocarcinoma tissues.[1][2][3][4]

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319
• Consejos de prudencia: P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable