This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene
Inmunógeno
ACOT13 (NP_060943.1, 1 a.a. ~ 140 a.a) full-length human protein.
Anti-ACOT13 antibody produced in mouse is suitable for western blot anaysis.
Acciones bioquímicas o fisiológicas
ACOT13 (Acyl-CoA thioesterase 13) is highly involved in the regulation of hepatic lipid and glucose homeostasis. It maintains the intracellular concentration of hepatic free fatty acids (FFAs) and fatty acyl-CoAs under physiological conditions by forming a complex with phosphatidylcholine transfer protein (PC-TP). In liver, it controls the β-oxidation of fatty acids, which is highly crucial for entry of fatty acyl-CoAs into mitochondria.
Forma física
Solution in phosphate buffered saline, pH 7.4
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(5), 2209-2221 (2012-02-22)
Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoAs, but their biological functions remain unknown. Thioesterase superfamily member 2 (Them2; synonym Acot13) is a broadly expressed mitochondria-associated Acot. Them2 was previously identified as an interacting
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