SAB1300086

Anti-SOST (N-term) antibody produced in rabbit

Ig fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-CDD, Anti-DAND6, Anti-SOST1, Anti-VBCH
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: Ig fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: mouse, human
• técnicas: immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000; western blot: 1:100-1:500
• Nº de acceso NCBI: NP_079513
• Nº de acceso UniProt: Q9BQB4
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... SOST(50964)

Descripción

Descripción general

SOST (sclerostin) gene codes for the protein sclerostin which is predominantly secreted by the osteocytes. The encoded protein is predominantly expressed in human woven and lamellar bone and mineralizing chondrocytes.

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Inmunógeno

SOST (NP_079513, 12-42)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SOST.

Aplicación

Anti-SOST (N-term) antibody produced in rabbit has been used in immunohistochemistry.

Acciones bioquímicas o fisiológicas

Sclerostin regulates bone remodeling in presence of mechanical stimulation. It has an inhibitory effect on the activation of osteoblasts by inducing phosphorylation and degradation of β-catenin. It downregulates bone formation and induces bone resorption. Mutation in this gene causes hyperostosis and leads to Van Buchem disease or sclerosteosis. Increased bone formation and enhanced healing of bone defects are observed upon selective deletion of the SOST gene in mice model. Sclerostin, a glycoprotein, is involved in vascular calcification. It might be associated with cardiovascular disorders.

Forma física

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable