SAB1300019

Anti-FGFR4 (N-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-Fibroblast growth factor receptor 4
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000; western blot: 1:100-1:500
• Nº de acceso NCBI: NP_002002
• Nº de acceso UniProt: P22455
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... FGFR4(2264)

Descripción

Descripción general

FGFR4 (fibroblast growth factor receptor 4) gene is located at chromosome 5q35.2. It is the most abundant FGFR isotype in mature liver cells. It is expressed in a temporal and spatially specific manner during development and in a cell type-specific manner in adult tissues.

FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

Inmunógeno

FGFR4 (29-66)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human FGFR4.

Aplicación

Anti-FGFR4 (N-term) antibody produced in rabbit has been used in immunohistochemistry.

Acciones bioquímicas o fisiológicas

Variations in the FGFR4 (fibroblast growth factor receptor 4) is associated with the advancement of various tumor types such as breast, prostate, colon, sarcoma tumors and ovarian cancer. Overexpression of FGFR4 is observed in diffuse-type gastric cancer and intestinal-type gastric cancer. FGFR4 is significantly involved in epithelial-to-mesenchymal transition, induced by tumor-associated fibroblasts. FGFR4 negatively regulates cholesterol metabolism and synthesis of bile acid in liver. Deletion of FGFR4 does not lead to embryonic damage, unlike other members of the FGFR family. FGFR4 serves as a prognostic and therapeutic biomarker for oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma.

Forma física

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable