S8065
Amyloid Precursor Protein α (304-612), Secreted human
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
Sinónimos:
sAPPα (304-612)
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About This Item
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Acciones bioquímicas o fisiológicas
Fragment of sAPPα designed to lack the N-terminal domain of the full length protein.
Secreted Amyloid Precursor Protein α (sAPPα) is a 612 amino acid protein produced from the ubiquitously expressed β-Amyloid precursor protein (βAPP), 695 isoform, by α-secretase cleavage. sAPPα (304-612) is a fragment of sAPPα designed to lack the N-terminal domain of the full length protein.
Forma física
0.2 μm filtered solution in phosphate buffered saline, pH 7.4.
Nota de preparación
Expressed as a soluble protein and purified under non-denaturing conditions.
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Mattson, M.P.
The Journal of Neuroscience, 25, 439-439 (1994)
Greenfield, J.P.,
Frontiers in Bioscience, 5, 72-72 (2000)
L W Jin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(9), 5461-5470 (1994-09-01)
Amyloid beta/A4 protein precursor (APP) is secreted into medium by most cultured cells and can function as an autocrine factor. To study the biological function of secreted forms of APP (sAPP) on neurons, we used a clonal CNS neuronal line
S W Barger et al.
Nature, 388(6645), 878-881 (1997-08-28)
A role for beta-amyloid precursor protein (beta-APP) in the development of Alzheimer's disease has been indicated by genetics, and many conditions in which beta-APP is raised have been associated with an increased risk of Alzheimer's disease or an Alzheimer's-like pathology.
Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease.
D J Selkoe
Annual review of cell biology, 10, 373-403 (1994-01-01)
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