S6201

Salinomycin, Ready Made Solution

from Streptomyces albus, ≥98% (HPLC)

• Sinónimos: Antibiotic 61477, Coxxistac
• Fórmula empírica (notación de Hill): C₄₂H₇₀O₁₁
• Peso molecular: 751.00
• Número MDL: MFCD25541652
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329824560
• NACRES: NA.77

Propiedades

• origen biológico: Streptomyces albus
• Nivel de calidad: 200
• Ensayo: ≥98% (HPLC)
• concentración: 2 mg/ml
• solubilidad: DMSO: soluble; H₂O: insoluble; alcohols: soluble; carbon tetrachloride: soluble; chloroform: soluble; ethers and esters: soluble; hexane: soluble
• espectro de actividad antibiótica: neoplastics
• Modo de acción: cell membrane | interferes
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: C[C@@H]1O[C@]([C@]2(C)CC[C@]3([C@H](O)C=C[C@]4(O[C@@]([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@@]5([H])[C@@H](C)CC[C@@]([C@H](C(O)=O)CC)([H])O5)=O)([H])[C@@H](C)C[C@H]4C)O3)O2)([H])CC[C@]1(O)CC
• InChI: 1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1
• Clave InChI: KQXDHUJYNAXLNZ-XQSDOZFQSA-N

Descripción

Descripción general

Chemical structure: polyether

Aplicación

Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells.[1] It has also been used in sequential treatment of cancer cells to study resistance.[2]

Acciones bioquímicas o fisiológicas

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule.[3] Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K⁺ over other monovalent and divalent cations.[3] Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K⁺ channels, which enhances cell proliferation.[4][5] Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs.[5] Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.[5]

Forma física

The product is supplied as a 2 mg/mL (2.66 mM) solution in DMSO, 0.2 μm-filtered.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 188.6 °F - closed cup
• Punto de inflamabilidad (°C): 87 °C - closed cup