S0445

Anti-Serotonin 5-HT_2B Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-5-HT(2B), Anti-5-HT-2B, Anti-5-HT2B
• Número MDL: MFCD01865274
• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• reactividad de especies: human
• disponibilidad: not available in Japan
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-6 μg/mL using human brain, neurons and glia
• Nº de acceso UniProt: P41595
• Condiciones de envío: wet ice
• temp. de almacenamiento: −70°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... HTR2B(3357) ; mouse ... Htr2b(15559) ; rat ... Htr2b(29581)

Descripción

Descripción general

Multiplbe genes encode different subtypes of serotonin (5HT) receptor and are species specific. HTR2B is expressed in mammalian brain and is localized to GABA (γ-aminobutyric acid) producing neurons of dorsal hypothalamic nucleus. The HTR2B gene is mapped to human chromosome 2q37.1.

Inmunógeno

synthetic peptide corresponding to the second extracellular loop of human serotonin 5-HT_2B receptor, conjugated KLH. The immunizing peptide has 80% homology with the rat gene and 93% homology with the mouse gene.

Acciones bioquímicas o fisiológicas

The functions of serotonin (5HT) receptors are associated with sleep disorders, anxiety, depression and schizophrenia.

Descripción de destino

The Serotonin 5-HT_2B Receptor regulates cardiomyocyte development and growth. Activation of 5-HT_2B receptors may also contribute to initiation of sleep and to theta generation during W and PS under physiological conditions.

Forma física

solution in phosphate buffered saline containing ≤0.1% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable