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RAB1020

Sigma-Aldrich

Human ADAMTS4 ELISA Kit

for cell culture supernatants, plasma, and serum samples

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About This Item

Código UNSPSC:
41116158
NACRES:
NA.32

reactividad de especies

human

envase

kit of 96 wells (12 strips x 8 wells)

técnicas

ELISA: suitable

entrada

sample type serum sample(s)
sample type plasma
sample type cell culture supernatant(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.12 ng/ml

método de detección

colorimetric

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... ADAMTS4(9507)

Descripción general

Human a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) enzyme-linked immunosorbent assay (ELISA) kit is an in vitro ELISA kit for the quantitative measurement of a human ADAMTS4 in biological samples, such as serum, plasma, cell culture supernatants, urine, and/or cell and tissue lysates. ADAMTS4 is a multidomain metalloproteinase that can inhibit the activity of aggrecan. It belongs to the ADAMTS family. ADAMTS4 is made up of a pro-domain, a catalytic metalloproteinase domain, a disintegrin-like (Dis) domain, a thrombospondin type I (TS) domain. It also contains a cysteine-rich (CysR) domain and a spacer (Sp) domain. ADAMTS4 gene is located on the human chromosome at 1q23.3.
This ELISA antibody pair detects Human ADAMTS-4

Aplicación

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Otras notas

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictogramas

Corrosion

Palabra de señalización

Warning

Frases de peligro

Consejos de prudencia

Clasificaciones de peligro

Met. Corr. 1

Código de clase de almacenamiento

8A - Combustible corrosive hazardous materials

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

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Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study
Wang X Z, et al.
Cancer Medicine, 8(18), 7869-7880 (2019)
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
Fushimi K, et al.
The Journal of Biological Chemistry, 283(11), 6706-6716 (2008)
Michael Stock et al.
Arthritis & rheumatology (Hoboken, N.J.), 69(6), 1233-1245 (2017-01-14)
Cartilage damage and subchondral bone changes are closely connected in osteoarthritis. Nevertheless, how these processes are interlinked is, to date, incompletely understood. This study was undertaken to investigate the mechanistic role of a cartilage-derived protein, upper zone of growth plate
Guping Mao et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 44(1), 38-52 (2017-12-15)
Aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5) are secreted enzymes belonging to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family that play significant roles in the progression of osteoarthritis (OA). Here, we aimed to determine whether the expression of ADAMTS-4/5
Jiyun Lee et al.
Experimental & molecular medicine, 52(4), 672-681 (2020-04-22)
Osteoarthritis (OA) is a common joint disease that results from the disintegration of joint cartilage and the underlying bone. Because cartilage and chondrocytes lack the ability to self-regenerate, efforts have been made to utilize stem cells to treat OA. Although

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