R9156

Raltitrexed

≥98% (HPLC), solid

• Sinónimos: L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl), ICI-D-1694, ZD-1694
• Fórmula empírica (notación de Hill): C₂₁H₂₂N₄O₆S
• Número de CAS: 112887-68-0
• Peso molecular: 458.49
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329824044
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: solid
• color: off-white to light yellow
• solubilidad: H₂O: ≥10 mg/mL; DMSO: ≥40 mg/mL
• emisor: AstraZeneca
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C1NC(C)=NC2=C1C=C(CN(C3=CC=C(C(N[C@H](CCC(O)=O)C(O)=O)=O)S3)C)C=C2

Descripción

Acciones bioquímicas o fisiológicas

Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H300,H360
• Consejos de prudencia: P201 - P301 + P310 + P330
• Clasificaciones de peligro: Acute Tox. 2 Oral - Repr. 1B
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges