Rsk1 is a ubiquitously expressed, mitogen-activated protein that belongs to the serine/threonine protein kinase family. It has a pivotal role in facilitating MEK-MAP kinase cell survival signaling and supressing pro-apoptotic function of BAD by its phosphorylation. Anti-phospho-Rsk1 (p90rsk) (pSer381) antibody can be used to detect Rsk1 when phosphorylated at phosphoserine 381. It can also be used in immunoprecipitation (diluted 1:200). Rabbit anti-phospho-Rsk1 (p90rsk) (pSer381) antibody reacts specifically with phosphorylated Rsk1 and not with nonphosphorylated Rsk1. The product has also specificity for Rsk1 of rat, mouse and human.
Inmunógeno
Synthetic phospho-Ser381 peptide corresponding to residues around Ser381 of human (p90rsk) conjugated to KLH.
Aplicación
Anti-phospho-Rsk1 (p90rsk) (pSer381) antibody can be used in western blotting (diluted 1:1000) using TPA-treated 293 cell extract. It can also be used in immunocytochemistry (diluted 1:2000).
Forma física
Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Growth factors activate an array of cell survival signaling pathways. Mitogen-activated protein (MAP) kinases transduce signals emanating from their upstream activators MAP kinase kinases (MEKs). The MEK-MAP kinase signaling cassette is a key regulatory pathway promoting cell survival. The downstream
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