R3405

RP-107

≥98% (HPLC), solid

• Sinónimos: 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
• Fórmula empírica (notación de Hill): C₁₆H₁₇N₃O
• Número de CAS: 496864-15-4
• Peso molecular: 267.33
• Número MDL: MFCD04973541
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329824024

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: solid
• condiciones de almacenamiento: desiccated
• solubilidad: DMSO: >10 mg/mL; H₂O: insoluble
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
• InChI: 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
• Clave InChI: PRIGRJPRGZCFAS-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel.

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC₅₀ = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

Características y beneficios

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves