NSP2, SH2 domain-containing protein 3B, SH2D3B, breast cancer antiestrogen resistance 3 protein, dJ1033H22.2 (breast cancer anti-estrogen resistance 3), novel SH2-containing protein 2
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100 μL
397,00 €
PLA0206-100UL
397,00 €
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The epitope recognized by PLA0206 maps to a region between residue 25 and 75 of human breast cancer anti-estrogen resistance 3 using the numbering given in entry NP_003558.1 (GeneID 8412).
BCAR3 (breast cancer anti-estrogen resistance 3) was originally identified as a factor that confers resistance to anti-estrogens in breast cancer cells. BCAR3 contains a Ras-GEF domain and an SH2 domain. It is related to SHEP1 and NSP1 and is thought to also play a role as an adaptor protein that mediates integrin signaling to modulate cell adhesion and migration.
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