P9255

Pyridoxal 5′-phosphate hydrate

≥98%

• Sinónimos: Pyridoxal phosphate, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate
• Fórmula empírica (notación de Hill): C₈H₁₀NO₆P · xH₂O
• Número de CAS: 853645-22-4
• Peso molecular: 247.14 (anhydrous basis)
• Beilstein: 234749
• Número CE: 200-208-3
• Número MDL: MFCD00006333
• Código UNSPSC: 12352205
• ID de la sustancia en PubChem: 24899020
• NACRES: NA.79

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥98%
• Formulario: powder
• técnicas: HPLC: suitable
• color: beige; off-white to yellow
• mp: 140-143 °C
• temp. de almacenamiento: −20°C
• cadena SMILES: CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O
• InChI: 1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
• Clave InChI: NGVDGCNFYWLIFO-UHFFFAOYSA-N

Descripción

Descripción general

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway.[1] It is the active form of pyridoxine.[2]

Aplicación

Pyridoxal 5′-phosphate hydrate has also been used:

• as a reference standard to quantify vitamin B₆ in feed and digesta samples using high performance liquid chromatography (HPLC)[3]
• in D-amino acid transaminase reaction(10)
• as a cofactor for L-glutamic acid decarboxylase[4]

Acciones bioquímicas o fisiológicas

Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis.[2] PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS)[5] cysteine desulfurase,[6] cystathionine γ-synthase (CGS),[7] ornithine 4,5-aminomutase (OAM),[8] and D-serine dehydratase.[9]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)