P7443

L-α-fosfatidilcolina

from soybean, ≥99% (TLC), lyophilized powder

• Sinónimos: 1,2-Diacil-sn-glicero-3-fosfocolina, 3-sn-Fosfatidilcolina, L-α-lecitina, Azolectina, PC
• Número de CAS: 8002-43-5
• Beilstein: 5209585
• Número CE: 232-307-2
• Código UNSPSC: 12352211
• NACRES: NA.25

Propiedades

• origen biológico: soybean
• Nivel de calidad: 200
• Ensayo: ≥99% (TLC)
• Formulario: lyophilized powder
• grupo funcional: phospholipid
• tipo de lípido: phosphoglycerides
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: [P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C
• InChI: 1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
• Clave InChI: JLPULHDHAOZNQI-ZTIMHPMXSA-N

Descripción

Descripción general

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk.[1] It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes.[2] It is essential for the acetylcholine synthesis functions to nourish the brain.[1] PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD).[3] It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease.[4] PC administration therapy is effective for treating benign symmetric lipomatosis.[5]

Aplicación

L-α-Phosphatidylcholine has been used:

• for liposome preparation[6]
• as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)[7]
• as a component of serum free substitute for whole blood cells[8]

Acciones bioquímicas o fisiológicas

Un fosfolípido estructural principal del cerebro, que constituye aproximadamente el 15% de los lípidos totales; localizado principalmente en la materia gris.

Envase

Packaged under Argon

Nota de preparación

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)