P6188

Prostaglandin I₂ sodium salt

≥96% (HPLC), synthetic, powder

• Sinónimos: Epoprostenol sodium
• Fórmula empírica (notación de Hill): C₂₀H₃₁NaO₅
• Número de CAS: 61849-14-7
• Peso molecular: 374.45
• Beilstein: 6472195
• Número CE: 263-273-7
• Código UNSPSC: 12352401
• eCl@ss: 42020658
• ID de la sustancia en PubChem: 24898653
• NACRES: NA.77

Propiedades

• origen biológico: synthetic
• Análisis: ≥96% (HPLC)
• formulario: powder
• color: white to off-white
• solubilidad: H₂O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F_1α in aqueous solution.); ethanol: 50 mg/mL
• grupo funcional: carboxylic acid; hydroxyl
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]
• InChI: 1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1
• Clave InChI: OURCVRVJQMLUNA-QFDVFERUSA-M

Descripción

Aplicación

Prostaglandin I2 sodium salt has been used:

• in the preparation of stock solution for platelet washing procedure
• as supplement in platelet-rich-plasma, for platelet preparation
• to prevent platelet activation

Acciones bioquímicas o fisiológicas

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A₂ and stimulating platelet adenylyl cyclase. Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves