P4904

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate

≥98%

• Sinónimos: 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-Palmityl-2-acetyl-sn-glycero-3-phosphocholine monohydrate, 2-Acetyl-1-hexadecyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1-hexadecyl-2-acetyl, PAF(C₁₆), Platelet activating factor
• Fórmula empírica (notación de Hill): C₂₆H₅₄NO₇P · xH₂O
• Número de CAS: 74389-68-7
• Peso molecular: 523.68 (anhydrous basis)
• Beilstein: 3574588
• Número MDL: MFCD00150679
• Código UNSPSC: 12352211
• ID de la sustancia en PubChem: 24898570
• NACRES: NA.77

Propiedades

• Análisis: ≥98%
• formulario: powder
• temp. de almacenamiento: −20°C
• cadena SMILES: O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
• InChI: 1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
• Clave InChI: HFMSDOHEENWULV-UFTMZEDQSA-N

Descripción

Aplicación

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine has been used:

• to study its effects on phagocytic activity and production of superoxide anion in equine alveolar macrophage and blood neutrophils
• to study its protective effects against cisplatin-induced cell death in a human melanoma cell line in vitro
• to determine its effects on cervical ripening and leukocyte infiltration in rat models

Acciones bioquímicas o fisiológicas

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine or platelet-activating factor (PAF), is a phospholipid, and a pro-inflammatory lipid mediator. It acts as a ligand for G protein-coupled platelet-activating factor (PAF) receptors and participates in several biological processes such as airway constriction, hypotension, platelet activation, and increased vascular permeability. PAF is released by various cells such as platelets, neutrophils, endothelial cells, and monocytes/macrophages. The levels of PAF are low in the blood due to its rapid metabolism by PAF acetylhydrolase and low production.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)