Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

N0290

Sigma-Aldrich

Nitazoxanide

≥98% (HPLC)

Sinónimos:

NTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización

Seleccione un Tamaño

10 MG
80,60 €
50 MG
299,00 €

80,60 €

Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Solicitar un pedido a granel
Todas las fotos(1)

Seleccione un Tamaño

Cambiar Vistas
10 MG
80,60 €
50 MG
299,00 €

About This Item

Fórmula empírica (notación de Hill):
C12H9N3O5S
Número de CAS:
55981-09-4
Peso molecular:
307.28
Número CE:
259-931-8
Número MDL:
MFCD00416599
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329818424
NACRES:
NA.77

80,60 €

Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Solicitar un pedido a granel

Ensayo

≥98% (HPLC)

Formulario

powder

emisor

Romark

temp. de almacenamiento

2-8°C

cadena SMILES

CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O

InChI

1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

Clave InChI

YQNQNVDNTFHQSW-UHFFFAOYSA-N

¿Está buscando productos similares? Visita Guía de comparación de productos

Descripción general

Nitazoxanide (NTZ), a thiazolide compound[1] is a antiparasitic drug with structure similar to niclosamide.[2]

Aplicación

Nitazoxanide has been used:
  • to test its anti-viral activity against chikungunya virus[3]
  • as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines[4]
  • to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells[5]

Acciones bioquímicas o fisiológicas

Nitazoxanide (NTZ) promotes autophagy by acting on kinase based signaling pathways[5] and acts on mammalian target of rapamycin complex 1 (mTORC1) in Mycobacteria.[2] It has anti-viral property and effectively halts entry and release of chikungunya virus in in vitro studies.[3] NTZ also inhibits Japanese encephalitis virus (JEV) infection in early stages and has the potential to treat other viral infections including dengue, hepatitis B (HBV), coronavirus and human immunodeficiency virus (HIV).[3] It has antineoplastic functionality and may induce apoptosis by promoting proto-oncogene c-Myc inhibition resulting in tumor suppression.[1]
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria.
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.

Características y beneficios

This compound was developed by Romark. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
0000296365
0000296365
0000160660
0000114613

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Benjamin Speich et al.
PLoS neglected tropical diseases, 6(6), e1685-e1685 (2012-06-09)
The currently used anthelmintic drugs, in single oral application, have low efficacy against Trichuris trichiura infection, and hence novel anthelmintic drugs are needed. Nitazoxanide has been suggested as potential drug candidate. The efficacy and safety of a single oral dose
Cirle A Warren et al.
Antimicrobial agents and chemotherapy, 56(8), 4103-4111 (2012-05-16)
Clostridium difficile infection (CDI) is a serious diarrheal disease that often develops following prior antibiotic usage. One of the major problems with current therapies (oral vancomycin and metronidazole) is the high rate of recurrence. Nitazoxanide (NTZ), an inhibitor of pyruvate:ferredoxin
Drug repurposing approach identifies inhibitors of the prototypic viral transcription factor IE2 that block human cytomegalovirus replication
Mercorelli B, et al.
Cell Chemical Biology, 23(3), 340-351 (2016)
Andrew Hemphill et al.
Expert opinion on pharmacotherapy, 7(7), 953-964 (2006-04-26)
Colonisation of the gastrointestinal tract by anaerobic bacteria, protozoa, trematodes, cestodes and/or nematodes and other infectious pathogens, including viruses, represents a major cause of morbidity and mortality in Africa, South America and southeast Asia, as well as other parts of
G Esmat et al.
Liver international : official journal of the International Association for the Study of the Liver, 32 Suppl 1, 146-150 (2012-01-11)
Hepatitis C virus genotype 4 (HCV-4) is the most common type of hepatitis C virus (HCV) in the Middle East and Africa, in particular Egypt. Since the development of new protease inhibitors, the response of HCV-4 to the standard regimen
Ver todos los artículos relacionados

Artículos

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Preguntas

Revisiones

Sin puntuación

Filtros activos

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico