MTOX1013
HepaRG™ Cells AHR (-/-)
human female liver (hepatocarcinoma and hepatitis C tumor)
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
1 vial | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 1250,00 € |
Acerca de este artículo
UNSPSC Code:
12352207
NACRES:
NA.81
Biological source:
human female liver (hepatocarcinoma and hepatitis C tumor)
1250,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleGeneral description
HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG AHR knockout cells express the major xenobiotic sensors (PXR and CAR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.
Application
See technical bulletin for detailed protocols
Features and Benefits
HepaRG cells are the most metabolically active human hepatocyte cell line developed to date. These the cells are suitable for a wide variety of studies for drug metabolism, CYP induction, metabolism-mediated toxicity, transporter, and hepatotoxicity. - Sigma′s HepaRG AHR Knockout (KO) allows conclusive identification of CYP1A1 and CYP1B1 induction through AHR activation.
Zinc finger nucleases (ZFN) mediated Knockout of AHR (AHR) gene.
- The frame-shift mutation of AHR gene was confirmed by fragment length analysis and DNA sequencing.
- Loss of functionality was confirmed by loss of response to inducers of cytochrome P450 activity.
Analysis Note
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification, cytochrome oxidase I (COI) analysis for cell line species confirmation.
Legal Information
Exhibit 1: ADME/Tox cell lines license
Exhibit 2: HepaRG limited use license
Exhibit 2: HepaRG limited use license
HepaRG is a trademark of BioPredic International company
1 of 1
Este artículo | |||
|---|---|---|---|
| description one vial, from human female liver(hepatocarcinoma and hepatitis C tumor) | description one vial | description 1 vial | description one vial |
| biological source human female liver (hepatocarcinoma and hepatitis C tumor) | biological source human female liver (hepatocarcinoma and hepatitis C tumor) | biological source human female liver (Source Disease: Hepatocarcinoma and Hepatitis C) | biological source human female liver (hepatocarcinoma and hepatitis C tumor) |
| storage temp. −196°C | storage temp. −196°C | storage temp. −196°C | storage temp. −196°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| OMIM accession no. | OMIM accession no. | OMIM accession no. | OMIM accession no. |
| Gene Information human ... AHR(196) | Gene Information human ... ABCC2(1244) | Gene Information human ... NR1I2(1337040) | Gene Information human ... EIF2AK3(9451) |
| form liquid | form liquid | form liquid | form liquid |
Clase de almacenamiento
12 - Non Combustible Liquids
¿Qué está pasando?
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
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