MTOX1001
MDR1 Knockout Caco-2 Cells
human male colorectal tissue (Source Disease: colon adenocarcinoma)
Sinónimos:
C2BBe1 Cells MDR1 (-/-/-/-)
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
1 vial | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 1890,00 € |
Acerca de este artículo
1890,00 €
Nombre del producto
MDR1 Knockout Caco-2 Cells, one vial
biological source
human male colorectal tissue (Source disease: colon adenocarcinoma)
Quality Segment
form
liquid
technique(s)
drug transporter assay: suitable, permeability assay: suitable
OMIM accession no.
application(s)
ADME/TOX
storage temp.
−196°C
Gene Information
human ... ABCB1(5243)
General description
Application
Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases
Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes
Caco-2 Transporter Knockout Cell Based Assays
Features and Benefits
- A functional knockout of the MDR1 gene eliminates the reliance on chemical inhibitors to determine if a compound is an MDR1 substrate
- The 24 well Transwell format enables the MDR1 knockout cells to be included in standard drug transporter protocols
- Human assay with no interference from animal inhibitors
- Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality
Legal Information
1 of 1
Este artículo | |||
|---|---|---|---|
| description one vial | description one vial | description one vial | description one vial |
| biological source human male colorectal tissue (Source disease: colon adenocarcinoma) | biological source human male colorectal tissue (Source Disease: colon adenocarcinoma) | biological source human male colorectal tissue (Source disease: adenocarcinoma) | biological source human male colorectal tissue (Source disease: adenocarcinoma) |
| technique(s) permeability assay: suitable, drug transporter assay: suitable | technique(s) drug transporter assay: suitable, permeability assay: suitable | technique(s) drug transporter assay: suitable, permeability assay: suitable | technique(s) drug transporter assay: suitable, permeability assay: suitable |
| storage temp. −196°C | storage temp. −196°C | storage temp. −196°C | storage temp. −196°C |
| OMIM accession no. | OMIM accession no. - | OMIM accession no. | OMIM accession no. |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| Gene Information human ... ABCB1(5243) | Gene Information human ... ABCC1(4363) | Gene Information human ... ABCB1(5243), ABCC2(1244) | Gene Information human ... ABCB1(5243), ABCG2(9429) |
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Los componentes del kit también están disponibles por separado
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
Clase de almacenamiento
12 - Non Combustible Liquids
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