This kit is sufficient to perform 100 tests in a 96-well plate format, including standards and duplicates. Please see the link below to review the product data sheet: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/125/489/mak257bul.pdf
MAK257
Tyrosinase Inhibitor Screening Kit (Colorimetric)
sufficient for 100 colorimetric tests
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About This Item
Código UNSPSC:
12161503
NACRES:
NA.25
Productos recomendados
aplicaciones
cosmetics
food and beverages
método de detección
colorimetric
enfermedades relevantes
dermatological diseases
temp. de almacenamiento
−20°C
Descripción general
Tyrosinase or polyphenol oxidase (EC 1.14.18.1), is an oxidoreductase that participates in the biosynthesis of melanin, a ubiquitous biological pigment found in hair, eyes, skin, etc. Inhibition of tyrosinase has been a long-time target in the skin health research, cosmetics and agricultural industries because of its role in browning reactions in skin pigmentation and during fruit harvesting and handling. Skin whitening and bleaching products utilize natural or synthetic tyrosinase inhibitors in order to lighten the skin color. Polyphenols, benzaldehyde derivatives, long-chain lipids, steroids, and natural compounds have been used as tyrosinase inhibitors.
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.[1]
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.[1]
Características y beneficios
Compatible with high-throughput handling systems.
Idoneidad
Suitable for screening/studying/characterizing tyrosinase inhibitors.
Principio
Tyrosinase catalyzes the oxidation of tyrosine, producing a chromophore that can be detected at 510 nm. In the presence of kojic acid, a reversible inhibitor of tyrosinase, the rate of oxidation of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of tyrosinase inhibitors. The assay is also adaptable to a 384 well format.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Dam. 1 - Resp. Sens. 1
Código de clase de almacenamiento
10 - Combustible liquids
Punto de inflamabilidad (°F)
188.6 °F
Punto de inflamabilidad (°C)
87 °C
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