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Merck

MAK184

Sigma-Aldrich

Succinate Colorimetric Assay Kit

Sufficient for 100 Colorimetric tests

Sinónimos:

Succinic Acid Assay Kit

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About This Item

Número CE:
Código UNSPSC:
12161503
NACRES:
NA.84

aplicaciones

cosmetics
food and beverages

método de detección

colorimetric

enfermedades relevantes

cardiovascular diseases; immunological diseases

temp. de almacenamiento

−20°C

Descripción general

Succinate (succinic acid) is a citric acid cycle intermediate and functions in the transport of electrons to the mitochondrial electron transport chain. It also functions in innate immune signaling and induces IL-1β production during inflammation. Succinates have been often used for the treatment of hypertension. Succinate measurements can be useful for studying its metabolic, immunological, and therapeutic activities.

Aplicación

Succinate Colorimetric Assay Kit has been used to measure the concentration of succinate.

Idoneidad

Suitable for the detection of succinate in a variety of samples such as cell and tissue culture supernatants and in liquid samples such as wine.

Principio

The Succinate Colorimetric Assay Kit is a highly sensitive assay for determining succinate levels (ranging from 2-10 nmole/well) in a variety of samples. Succinate concentration is determined by a coupled enzyme reaction, which results in a colorimetric (450 nm) product proportional to the succinate present.

Solo componentes del kit

Referencia del producto
Descripción

  • Succinate Assay Buffer

  • Succinate Converter

  • Succinate Enzyme Mix

  • Succinate Substrate Mix

  • Succinate Developer

  • Succinate Standard

Pictogramas

Health hazardCorrosion

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

Código de clase de almacenamiento

8A - Combustible corrosive hazardous materials


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Li J, et al.
Nature Communications, 8(1), 1322-1322 (2017)
Metoprolol succinate extended release/hydrochlorothiazide combination tablets.
Hainer JW and Jennifer S
Vascular Health, 3(3), 279-279 (2007)
Kimberly L Cramer-Morales et al.
Journal of Experimental Pathology, 1(2), 60-70 (2021-02-16)
Previous studies showed that human cell line HEK293 lacking mitochondrial superoxide dismutase (MnSOD) exhibited decreased succinate dehydrogenase (SDH) activity, and mice lacking MnSOD displayed significant reductions in SDH and aconitase activities. Since MnSOD has significant effects on SDH activity, and
Moran Fremder et al.
Cell reports, 36(6), 109521-109521 (2021-08-12)
The gut metabolite composition determined by the microbiota has paramount impact on gastrointestinal physiology. However, the role that bacterial metabolites play in communicating with host cells during inflammatory diseases is poorly understood. Here, we aim to identify the microbiota-determined output

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