MAK114
Glyoxalase I Activity Assay Kit
sufficient for 100 tests (UV)
Sinónimos:
Aldoketomutase Activity Assay, GLO1 Activity Assay, Ketone-Aldehyde Mutase, Activity Assa, Lactoylglutathione Lyase Activity Assay, Methylglyoxalase Activity Assay
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About This Item
Código UNSPSC:
12161503
NACRES:
NA.84
Productos recomendados
uso
sufficient for 100 tests (UV)
método de detección
colorimetric
enfermedades relevantes
cancer
temp. de almacenamiento
−20°C
Información sobre el gen
human ... GLO1(2739)
mouse ... GLO1(109801)
rat ... GLO1(294320)
Descripción general
Glyoxalase I (GLO-1), a lactoylglutathione lyase also known as methylglyoxalase, aldoketomutase, ketone-aldehyde mutase, and (R)-S-lactoylglutathione methylglyoxal-lyase, is an enzyme that catalyzes the isomerization of hemithioacetal adducts which are formed in spontaneous reactions between glutathionyl groups and aldehydes. The primary physiological function of glyoxalase I is the detoxification of methyglyoxal, a reactive 2-oxoaldehyde that is cytostatic at low concentrations and cytotoxic at millimolar concentrations. Glyoxalase I is a target for the development of pharmaceuticals against bacteria, protozoans, and cancer.
Aplicación
Glyoxalase I Assay Kit has been used to estimate the glyoxalase I activity in plasma samples.
Características y beneficios
Compatible with high-throughput handling systems.
Idoneidad
Suitable for the detection of Glyoxalase I activity in enzyme preparations and biological samples. Suitable for testing the effects of compounds on Glyoxalase I activity.
Principio
The Glyoxalase I Activity Assay kit provides a simple and direct procedure for measuring GLO-1 activity in a variety of samples such as enzyme preparations or biological samples. In this assay, the GLO-1-mediated production of S-lactoylglutathione is measured by monitoring the change in absorbance at 240 nm. One unit of Glyoxalase I is the amount of enzyme that will convert 1.0 μmole of S-lactoylglutathione from methylglyoxal and reduced glutathione per minute at pH 6.6 and 25 °C.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Muta. 2 - Skin Sens. 1
Código de clase de almacenamiento
12 - Non Combustible Liquids
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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