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Merck
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MAK060

Sigma-Aldrich

Fumarate Assay Kit

sufficient for 100 colorimetric tests

Sinónimos:

Fumarate Quantitative Assay Kit

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About This Item

Código UNSPSC:
12161503
NACRES:
NA.84

uso

sufficient for 100 colorimetric tests

método de detección

colorimetric

enfermedades relevantes

cancer

temp. de almacenamiento

−20°C

Descripción general

Fumarate is a tricarboxylic acid (TCA) cycle intermediate formed by the oxidation of succinate by succinate dehydrogenase. In the mammalian liver, Fumarate is also a product of the Urea cycle where its release in the cytosol leads to its conversion into malate and subsequently oxaloacetate while generating NADH in the cytosol. Deficiencies in fumarate hydratase are associated with increased cellular concentrations of fumarate and increased incidences of renal cell cancer. This is most likely due to fumarate-mediated upregulation of HIF1. The Fumarate Assay Kit provides a convenient tool for sensitive detection of the fumarate in a variety of samples.

Aplicación

Fumarate Assay Kit has been used to determine the concentration of fumarate in samples.

Idoneidad

Suitable for the detection of fumarate in a variety of samples including tissue, cells and serum

Principio

Fumarate is determined by an enzyme assay, which results in a colorimetric (450 nm) product, proportional to the fumarate present.

Pictogramas

Corrosion
GHS05

Palabra de señalización

Danger

Frases de peligro

H314

Clasificaciones de peligro

Eye Dam. 1 - Skin Corr. 1B

Código de clase de almacenamiento

8A - Combustible corrosive hazardous materials

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International journal of molecular sciences, 23(3) (2022-02-16)
The FH gene encodes the fumarate hydratase of the Krebs cycle and functions as a homotetramer to catalyze the hydration of fumarate to malate. Mutations in FH result in uterine leiomyomas, a rare autosomal dominant inherited metabolic disease. However, how
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