This product is sold by units and the vial content will vary from lot to lot. The minimum activity is 50 units/mg. The least amount that will be present in vial is 0.1 mg (100 ?g). The lot-specific activity is reported on the Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/US/en/product/sigma/m6908#product-documentation
M6908
Myeloperoxidase from human leukocytes
lyophilized powder, ≥50 units/mg protein
Sinónimos:
MPO, Peroxidase, myelo
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
5 units | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 469,00 € |
Acerca de este artículo
Número CAS:
NACRES:
NA.32
UNSPSC Code:
12352200
MDL number:
eCl@ss:
32160410
469,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarlebiological source
human leucocytes
Quality Segment
form
lyophilized powder
specific activity
≥50 units/mg protein
solubility
H2O: soluble, aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
SMILES string
[O+H2]O[O-]
InChI
1S/H2O3/c1-3-2/h1-2H
InChI key
JSPLKZUTYZBBKA-UHFFFAOYSA-N
Gene Information
human ... MPO(4353)
General description
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.
Application
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO
Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Biochem/physiol Actions
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).
Physical form
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Analysis Note
Source material tested and found negative for antibody to HIV and for HBSAG.
Other Notes
Lysosomal heme-containing protein.
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C
1 of 1
Este artículo | |||
|---|---|---|---|
| description lyophilized powder, ≥50 units/mg protein | description A lysosomal enzyme that catalyzes oxidations by hydrogen peroxide, including MPO-chloride-mediated killing of microbes and tumor cells, inactivation of chemotactic factors, and cross-linking of proteins. | description Highly stabilized, essentially salt-free, lyophilized powder, 200-300 units/mg solid (using pyrogallol) | description Type I, essentially salt-free, lyophilized powder, ≥50 units/mg solid (using pyrogallol) |
| biological source human leucocytes | biological source human | biological source horseradish | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| form lyophilized powder | form lyophilized | form essentially salt-free, lyophilized powder | form essentially salt-free, lyophilized powder |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. - | UniProt accession no. - |
| shipped in dry ice | shipped in wet ice | shipped in - | shipped in - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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how much MPO in mg or ug are on 5 units of Mpo
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