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Merck
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M4659

Sigma-Aldrich

Milrinone

≥97% (TLC), powder, phosphodiesterase type III inhibitor

Sinónimos:

1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile

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About This Item

Fórmula empírica (notación de Hill):
C12H9N3O
Número de CAS:
78415-72-2
Peso molecular:
211.22
Número CE:
278-903-6
Número MDL:
MFCD00133539
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
24278060
NACRES:
NA.77

product name

Milrinone, ≥97% (TLC), powder

Nivel de calidad

200

Análisis

≥97% (TLC)

formulario

powder

color

off-white

solubilidad

DMSO: >10 mg/mL
H2O: insoluble

emisor

Sanofi Aventis

temp. de almacenamiento

2-8°C

cadena SMILES

CC1=C(C=C(C#N)C(=O)N1)c2ccncc2

InChI

1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

Clave InChI

PZRHRDRVRGEVNW-UHFFFAOYSA-N

Información sobre el gen

human ... PDE3A(5139) , PDE3B(5140) , PDE4B(5142) , PDE5A(8654) , PTPRA(5786)
rat ... Pde3a(50678)

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Categorías relacionadas

Acciones bioquímicas o fisiológicas

Phosphodiesterase type III inhibitor; cAMP-specific, cGMP-inhibitable; potent cardiotonic, positive inotropic vasodilator.

Características y beneficios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Consejos de prudencia

P301 + P330 + P331 + P310

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Baozeng Xu et al.
Developmental biology, 385(2), 242-252 (2013-11-20)
The oocyte becomes competent for embryonic development by involving mutual communication with cumulus cells (CCs) during folliculogenesis. How this communication takes place under physiological conditions is not fully understood. Current study examined oocyte-CCs communication in the XY sex-revered female mouse.
Yuichiro Miura et al.
Pediatric research, 72(5), 490-494 (2012-08-14)
Previous studies aimed at developing an artificial placenta have had limited success. We hypothesized that the introduction of a high-performance membranous oxygenator to a pumpless artificial placenta could prolong the survival time of premature lambs. Immediately after delivery of the
Patrick J McNamara et al.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 14(1), 74-84 (2012-11-08)
Persistent pulmonary hypertension of the newborn is a common problem with significant morbidity and mortality. Inhaled nitric oxide is the standard care, but up to 40% of neonates are nonresponders. Milrinone is a phosphodiesterase III inhibitor which increases the bioavailability
Dirk Bassler et al.
The Cochrane database of systematic reviews, (11)(11), CD007802-CD007802 (2010-11-12)
Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome characterized by suboptimal oxygenation as a result of sustained elevation in pulmonary vascular resistance after birth. Currently, the therapeutic mainstay for PPHN is optimal lung inflation and selective vasodilatation
R Krams et al.
American heart journal, 121(6 Pt 2), 1951-1955 (1991-06-01)
Bipyridine derivatives have recently been introduced as a new class of inodilator drugs in the intravenous therapy of heart failure. A member of this class is milrinone, which improves the inotropic state and reduces ventricular afterload, leading to improved hemodynamics.
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