M0567
Microsomes from Liver, Pooled
from human male
Sinónimos:
lab equipment accessory
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1 VIAL
461,00 €
461,00 €
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1 VIAL
461,00 €
About This Item
Código UNSPSC:
12352204
NACRES:
NA.54
461,00 €
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origen biológico
human male
Nivel de calidad
Formulario
liquid
envase
vial of ~10 mg
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
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Aplicación
Microsomes from Liver, Pooled has been used:
- in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process[1]
- as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)[2]
- to study the metabolization of enantiomeric peptide D3[3]
Acciones bioquímicas o fisiológicas
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes. [6]
Source of drug metabolizing enzymes, including cytochrome P-450.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Los clientes también vieron
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
T OMURA et al.
The Journal of biological chemistry, 239, 2370-2378 (1964-07-01)
Sarvesh C Vashishtha et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(10), 1070-1076 (2002-09-14)
N-Glucuronidation at an aromatic tertiary amine of 5-membered polyaza ring systems was investigated for a model series of eight 1-substituted imidazoles in liver microsomes from five species. The major objectives were to investigate substrate specificities of the series in human
Mohamed W Attwa et al.
Drug design, development and therapy, 14, 4439-4449 (2020-10-31)
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Ali S Abdelhameed et al.
Royal Society open science, 6(6), 190434-190434 (2019-07-18)
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