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LO3300

Sigma-Aldrich

LOPAC®1280 (International Version)

Sinónimos:

Library of Pharmacologically Active Compounds

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About This Item

Código UNSPSC:
41106609
NACRES:
NA.77

formulario

liquid

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Descripción general

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO in archival storage racks).

Aplicación

LOPAC®1280 (International Version) has been used to screen chemical inhibitors with dephosphorylation activity. It has also been used in MyoScreen myotubes to screen for muscle regeneration molecules.

Características y beneficios

Collection of approximately 1,280 pharmacologically active Sigma compounds.
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apotosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:

  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Sigma-RBI Product Number (for easy re-order)
  • Rack Position

Otras notas

For sale outside of the U.S. only. U.S. customers should refer to Product Code LO1280.

Información legal

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Punto de inflamabilidad (°F)

188.6 °F - closed cup

Punto de inflamabilidad (°C)

87 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Shinohara Y, et al.
Molecular Cell, 67(5), 783-798 (2017)
Nicolas Wyhs et al.
Journal of biomolecular screening, 19(7), 1060-1069 (2014-03-13)
Methylated DNA binding proteins such as Methyl-CpG Binding Domain Protein 2 (MBD2) can transduce DNA methylation alterations into a repressive signal by recruiting transcriptional co-repressor complexes. Interfering with MBD2 could lead to reactivation of tumor suppressor genes and therefore represents
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The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and H3K56ac are vital for replication-coupled nucleosome assembly and genotoxic resistance in yeast and pathogenic
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Molecular pharmacology, 72(1), 1-7 (2007-04-05)
Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of
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LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

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