L9043

Lysostaphin from Staphylococcus simulans

recombinant, expressed in E. coli, lyophilized powder

• Sinónimos: Glycyl-glycine Endopeptidase
• Número de CAS: 9011-93-2
• Comisión internacional de enzimas: 3.4.24.75 (BRENDA, IUBMB)
• Número MDL: MFCD00131556
• Código UNSPSC: 12352204
• NACRES: NA.54

Propiedades

• origen biológico: bacterial
• recombinante: expressed in E. coli
• Análisis: ≥90% (HPLC)
• formulario: lyophilized powder
• actividad específica: ≥3000 unit/mg solid
• técnicas: molecular cloning: suitable
• idoneidad: suitable for sequence analysis test
• aplicaciones: life science and biopharma
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Lysostaphin, a zinc metalloenzyme, is mainly secreted as a proenzyme. It acts as an anti-staphylococcal agent and is highly stable at pH 4 and 5°C.

Aplicación

Lysostaphin from Staphylococcus simulans has been used in a study to assess molecular cloning, sequencing, and expression of lytM, a unique autolytic gene of Staphylococcus aureus. It has also been used in a study to investigate the sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity.

Acciones bioquímicas o fisiológicas

A protein complex with highly specific lytic activity against Staphylococcus species, including Staphylococcus aureus.

Lysostaphin possesses a lytic action against Staphylococcus aureus, which is used to treat antibiotic-resistant staphylococcal infections. It has the properties of enzymes, such as glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acetyl muramyl-L-alanine amidase. Lysostaphin is also used as a preservative in food industry and in clinical labs for rapid screening.

The antimicrobial activity of lysostaphin, a metalloendopeptidase expressed by Staphylococcus simulans, is enhanced by binding to the C′ terminus of the membrane-associated Trap protein of Staphylococcus aureus.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H334
• Consejos de prudencia: P261 - P284 - P501
• Clasificaciones de peligro: Resp. Sens. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)