L4295

LDN-91946

≥98% (HPLC)

• Sinónimos: 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
• Fórmula empírica (notación de Hill): C₁₅H₁₀N₂O₄S
• Número de CAS: 439946-22-2
• Peso molecular: 314.32
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: protect from light
• color: brown
• solubilidad: DMSO: ≥10 mg/mL
• temp. de almacenamiento: 2-8°C

Descripción

Acciones bioquímicas o fisiológicas

LDN-91946 is a potent, selective and uncompetitive UCH-L1 inhibitor that targets the enzyme-substrate complex, but not the free enzyme. Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme. It is one of the most abundant proteins in the brain. UCKL1 plays a key role in processing polyubiquitin and ubiquitylated proteolytic peptides. The enzyme has been linked to Parkinson disease and lung cancer. LDN-91946 inhibits UCH-L1-catalyzed substrate hydrolysis in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme. The compound is quite specific and is exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 μM. Compound was recently launched by Calbiochem. LDN-57444 is acts as competitive inhibitor.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable