K1632
Kininogen high molecular weight, Two Chain from human plasma
lyophilized powder
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About This Item
Productos recomendados
origen biológico
human plasma
Nivel de calidad
formulario
lyophilized powder
solubilidad
H2O: soluble 0.1 mg protein/mL
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... KNG1(3827) , KNG1 (includes EG:3827)
Descripción general
HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein.
High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex.
Acciones bioquímicas o fisiológicas
High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets.
High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis.
Envase
Package size based on protein content
Forma física
Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl
Nota de preparación
Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Henri Weidmann et al.
Biochimica et biophysica acta. Molecular cell research, 1864(11 Pt B), 2118-2127 (2017-07-27)
The contact system is a potent procoagulant and proinflammatory plasma protease cascade that is initiated by binding ("contact")-induced, auto-activation of factor XII zymogen. Formed active serine protease FXIIa then cleaves plasma prekallikrein to kallikrein that in turn liberates the mediator
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