I2273

3-Indoleacrylic acid

BioReagent, ≥98% (HPLC)

• Sinónimos: 3-(3-Indolyl)acrylic acid, IAA
• Fórmula empírica (notación de Hill): C₁₁H₉NO₂
• Número CAS: 1204-06-4
• Peso molecular: 187.19
• UNSPSC Code: 12352106
• NACRES: NA.52
• PubChem Substance ID: 24895972
• EC Number: 214-872-7
• Beilstein/REAXYS Number: 6317
• MDL number: MFCD00005633
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• grade: Molecular Biology
• Quality Segment: 100
• product line: BioReagent
• assay: ≥98% (HPLC)
• form: powder
• mol wt: 187.19 g/mol
• storage temp.: room temp
• SMILES string: OC(=O)\C=C\c1c[nH]c2ccccc12
• InChI: 1S/C11H9NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-7,12H,(H,13,14)/b6-5+
• InChI key: PLVPPLCLBIEYEA-AATRIKPKSA-N

Descripción

General description

3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription. This expression system requires that the gene of interest is cloned in plasmids containing the trpE promoter.

Application

3-Indoleacrylic acid has been used in the induction of ribokinase expression in E. coli.

Biochem/physiol Actions

3-Indoleacrylic acid (IAA) is metabolized from tryptophan and this conversion is carried out by gut microflora. 3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription. The IAA induced expression system requires the gene of interest cloned in plasmids containing the trp promoter. It promotes the barrier functionality of the intestinal epithelial cells. IAA also favors anti-inflammatory response and is regarded as a potential therapeutic to treat inflammatory bowel disease (IBD). It is also implicated in a variety of cellular processes including apoptosis, autophagy, cell proliferation and migration. In tumor cells, IAA is also reported to hinder tryptophan metabolism.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves