I2273

3-Indoleacrylic acid

BioReagent, ≥98% (HPLC)

• Sinónimos: 3-(3-Indolyl)acrylic acid, IAA
• Fórmula empírica (notación de Hill): C₁₁H₉NO₂
• Número de CAS: 1204-06-4
• Peso molecular: 187.19
• Beilstein: 6317
• Número CE: 214-872-7
• Número MDL: MFCD00005633
• Código UNSPSC: 12352106
• ID de la sustancia en PubChem: 24895972
• NACRES: NA.52

Propiedades

• grado: Molecular Biology; for molecular biology
• Línea del producto: BioReagent
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• mol peso: 187.19 g/mol
• temp. de almacenamiento: room temp
• cadena SMILES: OC(=O)\C=C\c1c[nH]c2ccccc12
• InChI: 1S/C11H9NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-7,12H,(H,13,14)/b6-5+
• Clave InChI: PLVPPLCLBIEYEA-AATRIKPKSA-N

Descripción

Descripción general

3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription. This expression system requires that the gene of interest is cloned in plasmids containing the trpE promoter.

Aplicación

3-Indoleacrylic acid has been used in the induction of ribokinase expression in E. coli.[1]

Acciones bioquímicas o fisiológicas

3-Indoleacrylic acid (IAA) is metabolized from tryptophan and this conversion is carried out by gut microflora.[2] 3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription.[3] The IAA induced expression system requires the gene of interest cloned in plasmids containing the trp promoter.[3] It promotes the barrier functionality of the intestinal epithelial cells. IAA also favors anti-inflammatory response and is regarded as a potential therapeutic to treat inflammatory bowel disease (IBD).[4] It is also implicated in a variety of cellular processes including apoptosis, autophagy, cell proliferation and migration. In tumor cells, IAA is also reported to hinder tryptophan metabolism. [5]

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves