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H8283

Sigma-Aldrich

Hemocyanin from Megathura crenulata (keyhole limpet)

PBS solution

Sinónimos:

KLH, Keyhole limpet hemocyanin

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50 MG
206,00 €
100 MG
320,00 €
500 MG
1080,00 €

206,00 €


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50 MG
206,00 €
100 MG
320,00 €
500 MG
1080,00 €

About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.25

206,00 €


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origen biológico

Megathura crenulata

Nivel de calidad

Formulario

PBS solution

concentración

3.0-7.0 mg/mL protein (A280)

contenido de cobre

0.10-0.30% (based on protein)

técnicas

ELISA: suitable

temp. de almacenamiento

2-8°C

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Descripción general

Gastropod hemocyanins are massive glycoproteins (4 to 8 MDa) designed by an intricate arrangement of 10 subunits that are self-assembled into hollow cylinders 35 nm in diameter.[1]
Hemocyanin is a high molecular weight copper containing glycoprotein. It reversibly binds oxygen and forms the extra-cellular respiratory protein of mollusks. Keyhole limpet hemocyanin (KLH) is filtered from the hemolymph of Megathura crenulata, also called the giant keyhole limpet. It is native to the southern California coast and Mexico.[1]

Aplicación

Keyhole limpet hemocyanin (KLH) is a strong and well known immune-stimulant in both experimental animals and humans. It has been used as a hapten carrier protein to enhance antigen-specific T cell priming and is known to stimulate a CD4+ T-cell response.[1]
Hemocyanin was used to study if antipeptide antibodies specifically recognize the l1 protein of the human papilloma virus of type 31.[2] It was also used to study the acid-induced unfolding of didecameric keyhole limpet hemocyanin. [3]

Forma física

Solution in PBS, pH 7.2, containing 1mM CaCl2 and 0.5 mM MgCl2 with 15 mM sodium azide as preservative

Nota de preparación

Chromatographically purified.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Juan Cordero-Solorzano et al.
Genetics, selection, evolution : GSE, 54(1), 68-68 (2022-10-24)
A sufficient IgG content in the colostrum is essential for the newborn calf, as it provides passive immunity which substantially affects the probability of survival during rearing. Failure of passive transfer (FPT) occurs when a calf does not absorb enough
Hendrikus J Wijnen et al.
Frontiers in veterinary science, 8, 784869-784869 (2022-01-01)
Resilient animals can cope with environmental disturbances in life with minimal loss of function. Resilience can be enhanced by optimizing early-life conditions. In poultry, eggshell temperature (EST) during incubation and early feeding are two early-life conditions that are found to
Ankita Varshney et al.
Amino acids, 39(3), 899-910 (2010-03-10)
Keyhole limpet hemocyanin (KLH) is widely used as an immune stimulant and hapten carrier derived from a marine mollusc Megathura crenulata. To provide details of the stability and equilibrium of KLH, different intermediate species were investigated with a series of
S M Andreev et al.
Bioorganicheskaia khimiia, 38(6), 667-675 (2013-04-04)
Antibodies that specifically recognize the capsid protein (L1) of human papillomavirus (HPV) are an important tool necessary for designing vaccines against HPV infection. In this work, we have predicted and synthesized peptide fragments mimicking B cell epitopes of L1 HPV
L R Ferguson et al.
Mutation research, 158(1-2), 89-95 (1985-10-01)
The tannins, delphinidin and procyanidin were isolated from flowers of white clover (Trifolium repens) and the leaves of Arnot Bristly Locust (Robina fertilis) respectively, and tested for mutagenic properties in a range of systems. There was no evidence for either

Preguntas

  1. Are there any contaminants (for example IgG, IgM) in H8283?

    1 respuesta
    1. As listed in the 'DESCRIPTION' section of the Product Detail Page, this product is a solution in PBS, pH 7.2, containing 1 mM CaCl2 and 0.5 mM MgCl2 with 15 mM sodium azide as a preservative. Unfortunately, this product is not tested for contaminants.

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