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H2644

1-O-Palmityl-2-O-methyl-rac-glycerol

Name: 1-O-Palmityl-2-O-methyl-<I>rac</I>-glycerol
Brand: SIGMA

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About This Item

Fórmula empírica (notación de Hill):

C₂₀H₄₂O₃

Número de CAS:

111188-59-1

Peso molecular:

330.55

Número MDL:

MFCD00079344

Código UNSPSC:

12352200

En este momento no podemos mostrarle ni los precios ni la disponibilidad

temp. de almacenamiento

−20°C

cadena SMILES

CCCCCCCCCCCCCCCCOCC(CO)OC

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

079F0668

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Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway.

T Syrovets et al.

Blood, 89(12), 4574-4583 (1997-06-15)

We have previously reported that the serine protease plasmin generated during contact activation of human plasma triggers biosynthesis of leukotrienes (LTs) in human peripheral monocytes (PMs), but not in polymorphonuclear neutrophils (PMNs). We now show that purified plasmin acts as

Phosphatidylinositol transfer proteins and protein kinase C make separate but non-interacting contributions to the phosphorylation state necessary for secretory competence in rat mast cells.

J A Pinxteren et al.

The Biochemical journal, 356(Pt 1), 287-296 (2001-05-05)

Mast cells permeabilized by streptolysin O undergo exocytosis when stimulated with Ca(2+) and guanosine 5'-[gamma-thio]triphosphate but become progressively refractory to this stimulus if it is delayed. This run-down of responsiveness occurs over a period of 20-30 min, during which the

1-O-hexadecyl-2-Q-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophils.

I M Kramer et al.

The Journal of biological chemistry, 264(10), 5876-5884 (1989-04-05)

To assess the role of protein kinase C (Ca2+/phospholipid-dependent enzyme) in the activation of the human neutrophil respiratory burst, we have utilized an ether lipid of the type 1-O-alkyl-2-O-methylglycerol (AMG), recently shown to be an inhibitor of this kinase. AMG-C16

The influence of ether lipid (AMG) on histamine release from isolated rat mast cells: synergistic interaction with TPA indicates protein kinase C activation.

N Grosman

Immunopharmacology, 20(2), 143-149 (1990-09-01)

We have previously shown that the ether lipid AMG (1-O-hexadecyl-2-O-methyl-sn-glycerol) has both synergistic and inhibitory effects on mast cell responses to the ionophore A23187. The present investigation showed only inhibitory effects of AMG in antigen- and compound 48/80-induced histamine release.

Phospholipid metabolism in bradykinin-stimulated human fibroblasts. II. Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C.

W J van Blitterswijk et al.

The Journal of biological chemistry, 266(16), 10344-10350 (1991-06-05)

Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic acid (PA) and diacylglycerol (DG) (Van Blitterswijk, W.J., Hilkmann, H., de Widt, J., and Van der Bend

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