GS60
GST A1-1, Recombinant Human
Sinónimos:
GST-epsilon, GST2, GSTA1-1, GTH1, glutathione S-transferase alpha 1
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.26
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in E. coli
Análisis
>95% (SDS-PAGE)
formulario
frozen liquid
actividad específica
21.04 units/mg protein
mol peso
23 kDa
concentración
2.0 mg/mL
temp. de almacenamiento
−70°C
Información sobre el gen
human ... GSTA1(2938)
Descripción general
using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.
Acciones bioquímicas o fisiológicas
Glutathione S-transferase alpha 1 (GSTA1) is an enzyme that in humans is encoded by the GSTA1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
The GSTA1 gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.
Almacenamiento y estabilidad
The enzyme should be used by the end-user customer within 1 year of receipt.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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