G3381

Geldanamycin from Streptomyces hygroscopicus

≥98% (HPLC), powder

• Sinónimos: NSC 122750
• Fórmula empírica (notación de Hill): C₂₉H₄₀N₂O₉
• Número de CAS: 30562-34-6
• Peso molecular: 560.64
• Número MDL: MFCD00274570
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329799914
• NACRES: NA.77

Propiedades

• esterilidad: non-sterile
• Nivel de calidad: 300
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: yellow to orange
• solubilidad: DMSO: soluble
• espectro de actividad antibiótica: neoplastics
• Modo de acción: enzyme | inhibits
• temp. de almacenamiento: −20°C
• cadena SMILES: CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• Clave InChI: QTQAWLPCGQOSGP-KSRBKZBZSA-N

Descripción

Descripción general

Chemical structure: benzenoid

Acciones bioquímicas o fisiológicas

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)